Journal of Neuroinflammation
Protein loss promotes age-linked brain cell activation in mice
In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.In experiments, aged mice lacking the protein showed stronger age-linked brain cell activation, but no obvious loss of nerve insulation or faster decline in movement.
Mouse studyMechanisms
Who was studiedAdult and aged mice, against aged control mice
What changedAged mice lacking SIRPα showed more age-linked brain cell activation than aged controls
The catchThe experiments did not distinguish adaptive activation from an early, compensated stage of persistent activation