GW3965
GW3965 has been studied in 2 papers since 2016: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Sep 24, 2021: “LXR agonist Prevents Peripheral Neuropathy and modifies PNS immune cells in Aged Mice”.
At a glance
The findings reach mice, none yet in people. 2 independent labs in 2 countries.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Departamento Administrativo de Ciencia, Tecnología e Innovación and 2 more
- Animals2
What did studies of GW3965 find?
6Studies of GW3965 measured 6 outcomes, among them nerve fibers of the sub-basal plexus, amyloid-beta and microvascular morphology.
Nerve fibers of the sub-basal plexus
upin mice1
1 study
Nerve fibers of the sub-basal plexus
upin mice1
GW3965 increases nerve fibers of the sub-basal plexus in mice (aged mice).
“Treatment resulted in a significant increase in nerve fibers of the sub-basal plexus”
Animalsaged micesub-basal plexus3 months
LXR agonist Prevents Peripheral Neuropathy and modifies PNS immune cells in Aged Mice
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Amyloid-beta
downin mice1
1 study
Amyloid-beta
downin mice1
GW3965 decreases amyloid-beta in 3xTg-AD mice.
“these changes were associated with decreased Aβ in blood vessels.”
Animalsin 3xTg-AD miceoralblood vessels
Neuroscience letters
Microvascular morphology
upin mice1
1 study
Microvascular morphology
upin mice1
GW3965 improves microvascular morphology in 3xTg-AD mice.
“partially restored microvascular morphology by decreasing tortuosity and increasing length as shown by Lectin immunostaining.”
Animalsin 3xTg-AD miceoralhippocampal microvasculature
Neuroscience letters
LRP1
upin mice1
1 study
LRP1
upin mice1
GW3965 increases LRP1 in 3xTg-AD mice.
“GW3965 increased LRP1 levels in neuron-like cells”
Animalsin 3xTg-AD miceoralneuron-like cells
Neuroscience letters
Activation of microglia
no changein mice1
1 study
Activation of microglia
no changein mice1
GW3965 showed no clear effect on activation of microglia in 3xTg-AD mice.
“astrogliosis, but not activation of microglia, decreased in very old (24 months) 3xTg-AD mice treated with GW965.”
Animalsin 3xTg-AD miceoral
Neuroscience letters
Astrogliosis
downin mice1
1 study
Astrogliosis
downin mice1
GW3965 decreases astrogliosis in 3xTg-AD mice.
“astrogliosis, but not activation of microglia, decreased in very old (24 months) 3xTg-AD mice treated with GW965.”
Animalsin 3xTg-AD miceoral
Neuroscience letters
What is GW3965 linked with?
2Studies link GW3965 with 2 measures: macrophage cholesterol content and macrophage polarization.
Macrophage cholesterol content
mixedin mice1
1 study
Macrophage cholesterol content
mixedin mice1
GW3965 is associated with macrophage cholesterol content in mice (aged mice).
“accompanied by a change in polarization, metabolism, and cholesterol content of macrophages in the sciatic nerve.”
Animalsaged micesciatic nerve3 months
LXR agonist Prevents Peripheral Neuropathy and modifies PNS immune cells in Aged Mice
bioRxiv (Cold Spring Harbor Laboratory)Preprint
Macrophage polarization
mixedin mice1
1 study
Macrophage polarization
mixedin mice1
GW3965 is associated with macrophage polarization in mice (aged mice).
“accompanied by a change in polarization, metabolism, and cholesterol content of macrophages in the sciatic nerve.”
Animalsaged micesciatic nerve3 months
LXR agonist Prevents Peripheral Neuropathy and modifies PNS immune cells in Aged Mice
bioRxiv (Cold Spring Harbor Laboratory)Preprint