Action potential duration at 90% repolarization

1. Ranolazine decreases action potential duration at 90% repolarization in mouse cells (96.3 ± 14.8 vs. 49.2 ± 9.4 ms, P = 0.001).

   “When cells were exposed to the INa,L antagonist ranolazine (10 μM), INa,L declined in GDX cells (-1.9 ± 0.5 vs. -0.4 ± 0.2 pA/pF; P < 0.001) and APD90 was reduced”

   Cellsin GDX ventricular myocytesventricular myocytes10 μMmales

   Chronic testosterone deficiency increases late inward sodium current and promotes triggered activity in ventricular myocytes from aging male mice

   American journal of physiology. Heart and circulatory physiology·Jun 30, 2023

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1. Gonadectomy increases action potential duration at 90% repolarization in mouse cells (96.9 ± 3.2 vs. 55.4 ± 2.0 ms, P < 0.001).

   “Action potential duration at 70 and 90% repolarization (APD70 and APD90) was prolonged in GDX compared with sham myocytes (APD90, 96.9 ± 3.2 vs. 55.4 ± 2.0 ms; P < 0.001).”

   Cellsgonadectomy vs. shamventricular myocytesmales

   Chronic testosterone deficiency increases late inward sodium current and promotes triggered activity in ventricular myocytes from aging male mice

   American journal of physiology. Heart and circulatory physiology·Jun 30, 2023

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