Accelerated long-term forgetting

1. Autosomal dominant Alzheimer's disease mutation impairs accelerated long-term forgetting in humans.

   “ALF test score was significantly lower in mutation carriers than non‐carriers across the three tests.”

   Humansin presymptomatic ADAD mutation carriers vs non-carriers

   Neuroimaging correlates and prognostic utility of accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer's disease

   AAIC 2025 abstract·25 Dec 2025

1. Accelerated long-term forgetting predicts Alzheimer's disease symptom onset in humans (AUC=0.82 (story), AUC=0.73 (list)).

   “Story ALF (AUC=0.82) and list ALF (AUC=0.73) discriminated between those who did and did not develop symptoms.”

   Humanspredicting symptom onset in mutation carriersmedian 7 years

   Neuroimaging correlates and prognostic utility of accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer's disease

   AAIC 2025 abstract·25 Dec 2025

More on Alzheimer's disease symptom onset

1. Accelerated long-term forgetting is associated with prefrontal cortex cortical thickness in humans.

   “In mutation carriers, verbal ALF (list and story) was associated with lower baseline cortical thickness in the prefrontal cortex (PFC) across four contiguous regions bilaterally”

   Humansin presymptomatic ADAD mutation carriersprefrontal cortex

   Neuroimaging correlates and prognostic utility of accelerated long‐term forgetting in presymptomatic autosomal dominant Alzheimer's disease

   AAIC 2025 abstract·25 Dec 2025