2 papers6 findings
Global intrinsic capacity
downin humans1
Accelerated epigenetic aging is associated with global intrinsic capacity in humans (Age interactions: linear β = -1.17 (95% CI -2.02 to -0.33); quadratic β = -0.39 (95% CI -0.71 to -0.08)).
“accelerated epigenetic aging was associated with lower global IC, with a greater detrimental outcome associated with advancing chronological age”
HumansAssociation became more detrimental with advancing chronological agemedian follow-up 3.01 yearsn = 970
Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity
JAMA network open1 Jul 2026
NfL
upin humans1
Accelerated epigenetic aging is associated with NfL in humans.
“more consistent associations with increases in GFAP and NfL for morbidity- and mortality-trained clocks.”
Humansplasma
Epigenetic aging and blood based neurodegeneration markers in LASI-DAD
The journal of prevention of Alzheimer's disease14 May 2026
GFAP
upin humans1
Accelerated epigenetic aging is associated with GFAP in humans.
“more consistent associations with increases in GFAP and NfL for morbidity- and mortality-trained clocks.”
Humansplasma
Epigenetic aging and blood based neurodegeneration markers in LASI-DAD
The journal of prevention of Alzheimer's disease14 May 2026
Neurodegeneration markers
upin humans1
Accelerated epigenetic aging is associated with neurodegeneration markers in humans.
“Baseline accelerated epigenetic aging was associated with higher levels of neurodegenerative biomarkers, including pTau181, GFAP, and NfL”
Humansplasma
Epigenetic aging and blood based neurodegeneration markers in LASI-DAD
The journal of prevention of Alzheimer's disease14 May 2026
Poor work quality
upin humans1
Poor work quality is associated with accelerated epigenetic aging in humans.
“poor work quality (i.e., job insecurity, insufficient work hours, low wages) among workers in midlife are associated with accelerated epigenetic aging in later life.”
Humansamong workersn = 3,000
Journal of health and social behavior30 Apr 2026
Not working for pay
upin humans1
Not working for pay is associated with accelerated epigenetic aging in humans.
“a history of not working for pay and a history of poor work quality”
Humansn = 3,000
Journal of health and social behavior30 Apr 2026
Japan Society for the Promotion of ScienceJP¥43.2m
Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.Corticosterone treatment shifts DNA methylation profiles in young chicks toward those of older birds and reshapes longevity pathways.
A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.A cross-species single-cell atlas links injured human kidney cells and aged mouse kidneys to shared chromatin reorganization and impaired repair.