Assessing reactive astrogliosis in aging and across the Alzheimer's disease spectrum with SMBT‐1

Abstract

Background: Monoamine Oxidase‐B (MAO‐B) is overexpressed in reactive astrocytes around Aβ plaques. We characterized the performance of ¹⁸ F‐SMBT‐1 ‐a MAO‐B PET tracer‐ in aging and across the AD continuum.