16-gene LOY risk score

16-gene LOY risk score has no effect on overall survival in humans (HR 1.20, 95% CI 0.95–1.51).

“the OOF risk score was attenuated to non-significance after adjustment for a 19-gene proliferation meta-score (HR 1.20, 95% CI 0.95–1.51, p = 0.13”

Humansadjusted for 19-gene proliferation meta-scorelung adenocarcinomamalesn = 231

A genomically validated loss of chromosome Y transcriptional program is a modest prognostic signal independent of tumour stage in male lung adenocarcinoma

Research Square·7 Aug 2026Preprint

16-gene LOY risk score predicts overall survival in humans (HR 1.34 per SD, 95% CI 1.06–1.68).

“higher risk remained associated with OS after adjustment for stage and age (HR 1.34 per SD, 95% CI 1.06–1.68, p = 0.013)”

Humansadjusted for stage and agelung adenocarcinomamalesn = 231

A genomically validated loss of chromosome Y transcriptional program is a modest prognostic signal independent of tumour stage in male lung adenocarcinoma

Research Square·7 Aug 2026Preprint