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Therapeutic Induction of Dermal Remodeling in Veterans to Prevent Actinic Neoplasia Caused by Chronic Environmental Exposure to Ultraviolet Radiation
- Sponsor
- VA Office of Research and Development (US federal)
- Enrolment
- 96 planned
- Conditions
- Nonmelanoma Skin Cancer; Actinic Keratosis
- Interventions
- Microneedling; Trichloroacetic acid peel
- Ages
- adults, older adults
- Registry
- NCT07648407
From the registry
The investigators' previous studies demonstrate geriatric subject skin responds differently to ultraviolet B (UVB) light compared to young subject skin, which contribute to increased rates of nonmelanoma skin cancer (NMSC) and actinic keratosis (AK) development in geriatric populations. Previously, the investigators have shown that therapeutic dermal remodeling interventions (e.g., fractionated laser resurfacing and microneedling) can restore appropriate skin responses to UVB in geriatric skin. The investigators also demonstrated fractionated laser resurfacing (FLR) reduced rates of NMSC and AK development (compared to untreated control skin) in at risk geriatric subjects. This interventional study will assess the ability of two therapeutic dermal remodeling therapies, microneedling and trichloroacetic acid chemical (TCA) peel, to impact NMSC and AK development in at risk geriatric subjects. Geriatric subjects will be enrolled into one of two study groups. In the first group, one arm will be treated with microneedling and the other arm will not be treated on day 1. In the second…
Primary outcomes
- Change From Baseline in the Number of Actinic Keratosis due to treatment.
- Change From Baseline in the Number Non-Melanoma Skin Cancers due to treatment.