AnimalsBrain aging
Aging rhesus macaques display distinct fluid proteomic signatures of senescence and neuropathology
Plasma proteins tracked aging and amyloid pathology more closely than cerebrospinal fluid across the non-human primate lifespan.
Search results for IL6
21 results
- AnimalsMitochondria
Astragaloside IV reduces cardiac aging in mice by restoring mitochondrial balance
The compound lowered senescence markers and improved heart function through SIRT3-driven DRP1 deacetylation in aged mice and cultured cardiomyocytes.
ASXL1 mutations in clonal hematopoiesis accelerate aortic valve calcification
Large human cohort data and cell experiments show that ASXL1-driven clonal hematopoiesis worsens aortic valve hemodynamics and promotes calcification through inflammatory signaling.
- AnimalsCellular senescence
Baicalein reduces disuse-driven skeletal senescence and alters gut microbes in rats
Oral treatment restored bone density and mechanical strength while suppressing inflammatory markers and rebalancing intestinal bacteria in a disuse model.
- HumansCellular senescence
Plasma metabolic shifts link to T-cell senescence and mortality in older COVID-19 patients
Dysregulated phospholipid and bile acid metabolism tracked with cytokine spikes and 180-day mortality, while a specific lipid attenuated senescent markers in cell tests.
- AnimalsCellular senescence
Arsenic triggers heart senescence in mice while quercetin counteracts the damage
Exposure to environmental arsenic caused heart dysfunction via the p53 and p21 pathway, which quercetin treatment reversed in cultured rat cardiomyoblasts.
- HumansInflammaging
Age-linked immune profiles identify distinct risk groups for chronic obstructive pulmonary disease
Clustering four age-associated inflammatory cytokines separated adults into three distinct endotypes tied to early chronic lung disease risk.
- CellsInflammaging
Long-term human skin platform models chronic inflammation and senolytic treatments
The culture platform maintained native tissue architecture for four weeks, revealing treatment effects on aged donor tissue that emerged only after prolonged exposure.
- AnimalsBrain aging
Gastrodia elata polysaccharide extends worm lifespan and mitigates age-related deficits in mice
The treatment reduced oxidative stress, suppressed inflammation, and remodeled the gut microbiome in naturally aging mice while prolonging survival in nematodes.
- AnimalsInflammaging
Aging remodels mouse neutrophils across organs to drive inflammatory and senescence responses
Single-cell profiling reveals distinct neutrophil subsets that promote senescence in vascular and liver cells while altering bone marrow progenitor states.