Papers by Y. H. He

138 results

  1. Aging Cell

    Two compounds improved health-related measures in aging mice

    Experiments in mouse models of aging found reduced tissue senescence, in which cells stop dividing, alongside improvements in measures linked to healthy lifespan.Experiments in mouse models of aging found reduced tissue senescence, in which cells stop dividing, alongside improvements in measures linked to healthy lifespan.

    Experiments in miceInterventions
  2. Frontiers in Aging Neuroscience

    Spinal fluid protein linked to Alzheimer’s dementia risk

    An observational study of 444 people without dementia linked a blood vessel-related protein to poorer thinking, brain shrinkage and later Alzheimer’s dementia.An observational study of 444 people without dementia linked a blood vessel-related protein to poorer thinking, brain shrinkage and later Alzheimer’s dementia.

    Cohort study of 444 peopleAlzheimer's disease
  3. Clinical Epigenetics

    Biological aging and heart health link to lung disease risk

    A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases.A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases.

    Study in peoplePopulations
  4. Advanced Science

    Adult human lung cells became expandable precursor-like cells

    Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.Experiments with adult human lung cells produced cells that could multiply extensively and form three-dimensional models resembling mature lung air sacs.

    Experiments in human cellsLung
  5. International Immunopharmacology

    Rapamycin improves efferocytosis and reduces plaques in mice

    In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ±…In ApoE-/- mice, rapamycin reduced aortic lipid-positive area from 25.32 ± 0.98% to 12.28 ± 1.49% and increased plaque efferocytosis index from 0.36 ± 0.02 to 1.37 ± 0.15.

    Experiments in miceRapamycin
  6. Journal of Alzheimer's Disease Reports

    Statins cut Alzheimer's risk but raise other dementia risks

    A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease.A Mendelian randomization analysis found total cholesterol mediated 93.91% of statins' effect on overall dementia and 84.37% on dementia in Alzheimer's disease.

    Mendelian randomisation in peopleStatins