AgingResearch.NewsJoin free
Research Square

Analysis flags possible therapy-response markers in human muscle

A computational analysis used seven exercise datasets across three species to identify candidate therapy-response markers in Duchenne muscular dystrophy muscle biopsies.

Paper by Rangaprasad Sarangarajan · HealthLogiks
Figure 1. Fig. 1. Tri-context convergence of ANKRD2 across exercise, aging, and dystrophic muscle: (a) Schematic of the three independent datasets and physiological contexts.
Open the figure at full size
Figure 1. Fig. 1. Tri-context convergence of ANKRD2 across exercise, aging, and dystrophic muscle: (a) Schematic of the three independent datasets and physiological…Fig. 1. Tri-context convergence of ANKRD2 across exercise, aging, and dystrophic muscle: (a) Schematic of the three independent datasets and physiological contexts.Sarangarajan

Our read

Biomarkers
Studied:
Preprint: computational study
In the record:
The 1,681st paper on resistance training with results in people; 3,681 on record in all.

Editor of record: Boris Djordjevic · AgingResearch.News

Paper
Follow @agingbrief

Human muscle biopsy data from people with Duchenne muscular dystrophy were examined alongside exercise data in a computational study seeking candidate markers for tracking therapy responses. The analysis drew on seven independent exercise datasets spanning three species and scored 147 established muscle genes.

The stretch-sensing protein ANKRD2 showed a training-induced molecular pattern in healthy young muscle, a blunted pattern in long-term trained older adults, and lower levels in dystrophy biopsies. The authors used this pattern to anchor their search. Leading candidates included UCP3 and FBXO32, two proteins depleted in dystrophy biopsies that also showed evidence of increases with resistance training in aging muscle. Each had supporting RNA evidence from at least two independent Duchenne datasets. A separate gene-network analysis also supported UCP3.

Why it matters

The authors propose a link between weakened muscle adaptation with aging and disrupted muscle structure and signaling in Duchenne muscular dystrophy. They propose using the framework to select measures for early therapy trials.

Caveats

The computational analysis nominated candidates; it did not establish that their levels track responses to Duchenne therapies. The work is a preprint and has not been peer-reviewed.

Where the evidence stands

Exercise

Worms or flies, mice and humans: replicated by independent labs. Cells: a single group.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1,419 independent labs in 89 countries
  • 788 findings against
  • 282 trials, 21 with no results posted
  • Funders: National Institutes of Health and others
  • 371 of 7,870 findings with company ties

Resistance training

Mice and humans: replicated by independent labs. Cells: a single group. Worms or flies: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 666 independent labs in 73 countries
  • 343 findings against
  • 81 trials, 1 with no results posted
  • Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior and others
  • 173 of 3,740 findings with company ties

Comments

Be the first to comment.

Exercise is part of Bryan Johnson's Blueprint

More on Exercise