MechanismsAnimalsPreprint

The brain-meningeal interface functions as a reservoir and entry site for brain parenchymal macrophages

Research Square

Abstract

Microglia are regarded as self-maintaining brain parenchymal macrophages without contribution from adult hematopoiesis. While peripheral macrophage engraftment into the brain has been reported, the biological variables governing central nervous system (CNS) macrophage niche access remain unclear.

The paper

Hutter G, Kaymak D, Williams P et al.

Research Square · 7 Sep 2026 · CC BY · Preprint, not peer-reviewed

doi.org/10.21203/rs.3.rs-10893390/v1