The American Journal of Clinical Nutrition

Higher ultra-processed food intake linked to some blood cancers

Higher intake was associated with more new blood cancer diagnoses among 204,494 UK Biobank participants followed for a median 10.5 years.

Figure 1 from The American Journal of Clinical Nutrition
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Figure 1. Yu et al.
Cohort study of 204,494 UK Biobank participants without hospital-recorded myeloid neoplasmsPopulations

Independent replication

Limit: Hospital inpatient records could miss myeloid cancers managed entirely in outpatient care

Edited by Boris Djordjevic · AgingResearch.News

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An observational cohort study followed 204,494 UK Biobank participants without hospital-recorded myeloid neoplasms, a group of cancers affecting blood-forming cells. Researchers used dietary questionnaires to estimate the average share of dietary energy participants obtained from ultra-processed foods.

During a median 10.5 years, 848 participants received a new hospital-recorded diagnosis. Higher intake was associated with a higher rate of diagnosis after adjustment for demographic, behavioral and other measured factors. For each standard-deviation increase in the energy share—a step based on how widely intake varied among participants—the hazard ratio was 1.12. This ratio compares diagnosis rates during follow-up. Exploratory analyses of molecules in blood provided biological context but did not establish a causal pathway.

Why it matters

Myeloid cancers are relevant to healthy aging. The study addresses whether diet may be a factor in their development.

Caveats

This observational study cannot establish cause and effect. The findings concern UK Biobank participants and diagnoses recorded in hospital inpatient data.