Journal of the American Heart Association

Abdominal obesity linked to higher heart risk in diabetes

In normal-weight adults with type 2 diabetes, abdominal obesity was linked to higher combined death and cardiovascular risk, with a relative-risk measure of 1.13 versus no abdominal obesity.

Paper by Onyou Kim, Yong Hwan Park, Soo Yeon Kim, 4 more authorsKi Hong Choi · Korea University Anam Hospital
Graphical abstract from Journal of the American Heart Association
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Graphical abstract. Kim et al.
Cohort study of 323,029 normal-weight adults with newly diagnosed type 2 diabetes, median 6.0 yearsPopulations

Limit: Physical activity was self-reported and could be misclassified

Edited by Boris Djordjevic · AgingResearch.News

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This retrospective observational cohort study included 323,029 adults in South Korea with newly diagnosed type 2 diabetes and normal body mass index, below 23 kilograms per square meter. Researchers used insurance records and questionnaires about moderate-to-vigorous physical activity. Abdominal obesity meant a waist circumference of at least 90 centimeters in men or 80 centimeters in women.

Over a median six years, abdominal obesity was linked to higher combined risk of death from any cause, heart attack, stroke caused by blocked blood flow, or hospitalization for heart failure. The adjusted hazard ratio—a measure of relative risk over time—was 1.13 versus no abdominal obesity. Among participants with abdominal obesity, regular activity after diagnosis was linked to lower risk of this combined outcome, with an adjusted hazard ratio of 0.74 versus no regular activity.

Why it matters

Cardiovascular disease threatens health in later life. The study addressed whether waist size and physical activity could help distinguish risk among people with diabetes whose body mass index was normal.

Caveats

This observational study could not establish cause and effect, and participants reported their own activity. The findings do not establish the same associations in people without diabetes or with higher body mass index.