Environmental Science & Technology

Air pollution components linked to heart and lung problems

In older adults, a rise spanning the middle half of chloride exposure levels was linked to 3.48% higher blood pressure between heartbeats.

Paper by Yu Wang, Jianlong Fang, Xiang Zhao, 6 more authorsXiaoming Shi · Chinese Center For Disease Control and Prevention
Lungs with narrower airways beneath dense pollution particles face lungs with wider airways beneath sparse particles, with small groups of people below.
Cohort study of older adultsMechanisms

313 measurements

Limit: Blood pressure and a lung-function ratio served as proxies for heart and lung disease

Edited by Boris Djordjevic · AgingResearch.News

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In older adults, researchers used personal exposure monitoring in a longitudinal observational study with 313 measurements to examine fine-particle pollution and heart and lung function. They identified chloride, nickel, barium and selenium as key components associated with poorer function.

A rise spanning the middle half of nickel exposure levels was associated with a 0.09% decrease in a lung-function ratio: air exhaled in the first second of a forced breath divided by the total exhaled. The researchers also analyzed DNA methylation—chemical tags on DNA—and gene activity as possible links between exposure and these changes. Their analyses suggested possible roles for pathways involving nerve signaling, metabolism and cardiovascular function.

Why it matters

Heart and lung problems in older adults make it important to distinguish the risks linked to individual pollution components, rather than treating fine particles as a single exposure.

Caveats

This observational study could not establish that pollution components caused dysfunction or that the proposed molecular pathways mediated it. The abstract reported 313 measurements but did not give the number of participants or their age range.