CMTM6/PD-L1-targeted AAV promotes anti-tumor immune responses and chemotherapy responsiveness

Frontiers in Immunology

Abstract

Chemotherapy is one of the important clinical treatments for malignant tumors, but primary or acquired chemotherapy resistance significantly limits patient benefits. Programmed death ligand 1 (PD-L1) has been reported to be regulated by chemotherapy and to contribute to chemotherapy resistance.

The paper

Runqiu Chen, Xiaoyu Pang, Fanglin Li,
Show 12 more authorsShanna Wu, Yiting Wang, Xinhang Zheng, Yaqi Zhao, Fengru Qiu, Liying Chen, Fengyu Du, Chen Chen, Rong Zhang, Zhiying Li, Yiru Long, Likun Gong,
Meiqing Feng

Fudan University

Frontiers in Immunology · 14 Sep 2026 · CC BY

doi.org/10.3389/fimmu.2026.1886034PubMed 42807306