Novel Bioequivalent Sitagliptin and Metformin Bilayer Tablet with Improved Chemical Stability

Abstract

Objectives : Fixed-dose combination tablets containing sitagliptin hydrochloride (SG) and metformin hydrochloride (MF) are a mainstay in the clinical management of type 2 diabetes. However, SG is highly susceptible to chemical degradation during storage, particularly in the presence of MF.

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