Older rats had more severe bone changes with kidney disease
In an experiment, 17-month-old Brown Norway rats developed more severe bone abnormalities after induced chronic kidney disease than 3-month-old rats.
Limit: Bone turnover and porosity were measured; bone strength and fractures were not
Edited by Boris Djordjevic · AgingResearch.News
An experiment in 3-month-old and 17-month-old Brown Norway rats used adenine to induce chronic kidney disease. The older rats developed more severe bone abnormalities.
Bone turnover—the breakdown and rebuilding of bone—was high in all rats with kidney disease. Coverage of spongy bone surfaces by bone-removing cells was highest in older rats with the disease. The surface coverage and thickness of osteoid, bone material not yet hardened by minerals, were elevated only in older rats given adenine. Porosity in the dense outer bone was present only in older rats and increased with kidney disease.
Why it matters
Fractures become more common with age in people with chronic kidney disease. The authors identified this rat model as suitable for studying how aging and kidney disease interact in bone.
Caveats
The findings came from an induced-disease model in rats and do not establish how aging affects bones in people with chronic kidney disease.
- Cellular senescence
- Chronic kidney disease
- Chronic kidney disease-mineral and bone disorder
- Blood urea nitrogen
- Cellular senescence markers
- Rats
The paper
Indiana University School of Medicine; Richard L. Roudebush VA Medical Center
Bone, May 12, 2026
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