Isolation, purification, characterization and anti-aging potential of an extracellular polysaccharide AEPS-1 from Streptomyces sp. YJ06

An extracellular polysaccharide (AEPS-1) with novel structure and anti-aging potential was isolated and characterized from Streptomyces sp. YJ06. Structural analysis revealed AEPS-1 is a neutral gluco-mannopolysaccharide of low molecular weight (8513 Da) featuring a unique triple-helical conformation and a highly branched architecture. It demonstrated significant in vitro antioxidant activity, characterized by exceptional reducing power alongside moderate free radical scavenging capacity. Crucially, AEPS-1 effectively extended the chronological lifespan of Saccharomyces cerevisiae by alleviating oxidative damage, as evidenced by reduced malondialdehyde (MDA) and enhanced superoxide dismutase (SOD) activity. This study highlights AEPS-1 as a promising candidate for further development as a natural anti-aging agent.