Peptides as Master Keys to Skin Aging

BACKGROUND: Understanding skin aging and developing effective interventions represent fundamental challenges in dermatology. Key mechanisms driving this process include complex interactions among cellular senescence, extracellular matrix remodeling, oxidative stress, and inflammatory networks. SUMMARY: Recent advances have catalyzed the development of innovative peptide-based therapeutic strategies for skin aging. These include environment-responsive peptides, biomimetic peptides, and advanced nano-delivery systems. The integration of chronobiology and multi-omics analysis further supports the evolution of these approaches. KEY MESSAGES: We envision a new era of personalized solutions for skin aging, driven by the convergence of molecular understanding, delivery innovations, and precision medicine. This paradigm shift holds transformative potential not only for dermatology but also for broader aspects of human aging and health.