Bioscience, Biotechnology, and Biochemistry
A combination of exercise and calorie restriction improves the development of obesity-related type 2 diabetes mellitus in KKAy mice
By Sugimoto T, Uchitomi R, Onishi T et al.
Experiments in animalsInterventions
Abstract
We observed that exercise and calorie restriction reduced the body weight and blood glucose levels, concurrently improving insulin resistance and glucose tolerance in obese/diabetic model KKAy mice. Analysis of gene expression in the skeletal muscle showed enhanced mRNA levels of GLUT4 (glucose uptake), ATGL (lipolytic enzyme), and slow-twitch myosin heavy chain, which may contribute to the antiobesity and antidiabetic effects.
The paper
Sugimoto T, Uchitomi R, Onishi T et al.
Bioscience, Biotechnology, and Biochemistry, 29 Oct 2022
