Study Design and Demographics in Community Dwelling Adult Participants of the Osaka-Settsu Prospective Cohort Study for Health, Nutrition and Well-being (Preprint)

BACKGROUND In 2024, we launched the Osaka-Settsu Prospective Cohort Study for Health, Nutrition and Well-being (the Osaka-Settsu Study) in Japan. This population-based prospective study aimed to identify the risk factors for lifestyle-related diseases and care given and contribute to precision health care. OBJECTIVE This cohort profile paper describes the study design and the demographics of the participants. METHODS A self-administered questionnaire survey was mailed to registered residents aged ≥ 18 years in Settsu City from February to June 2024. The survey asked the participants about physical activity, nutritional status, well-being, and frailty. The participants will be followed up for the incidence of lifestyle-related diseases, need for support/long-term care certification, emergency transportation, and migration. RESULTS Of the 71,680 self-administered questionnaires distributed, 13,282 were completed. There were 7238 females and 5887 males. Mean age (standard deviation) were 62.1 (17.6) and 60.7 (18.4) years for females and males, respectively. The number of participants was highest in 70-79 year age group for both female and male participants. The body mass index tends to increase with age in female, in contrast, that increased with age, peaked in the 50s, and declined thereafter in male. CONCLUSIONS This study is planned to collect information on vital status and conducts follow-up surveys to identify the predictors of functional decline across the course of life. This study provides valuable evidence for the development of strategies to extend a healthy lifespan. CLINICALTRIAL