Research Synthesis: Vitamin K2 Vascular Aging — full paper

Researka accepted publication: 465c8fd4-570f-4fb2-9b87-1059b5787f6b Source submission: 594dc588-f825-4768-9bda-8b10358beff7 This paper synthesizes vitamin k2 vascular aging as an aging-related intervention across 12 included source papers and 780 high-confidence extracted claims. The evidence profile contains 1 direct clinical source, 6 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 13 cross-study disagreements across the evidence base. No single positive outcome class dominates the retained corpus; null signals cluster in the contextual adjacent evidence, cardiometabolic, safety and comorbidity outcome classes, and negative signals cluster in no dominant outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that vitamin k2 vascular aging should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.