Hypothesis-Generating Brief: Sirtuin Intervention Aging Effects — full paper

Researka accepted publication: 55c23130-2789-4619-9045-518911e27dd1 Source submission: 75c23474-39a9-49c5-98a3-25e8a95b8f65 Evidence-honesty note: 36/41 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the source texts contain no directional findings; source-level positive, negative, or unclear findings should be interpreted through the coded outcome class, directness, and claim-count fields. 38/41 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims. This paper synthesizes evidence on sirtuin intervention aging effects across 41 accepted source papers and 1394 high-confidence extracted claims. The evidence profile contains 3 direct clinical sources, 37 adjacent clinical sources, and 1 mechanistic or model-system source, with 116 cross-study disagreements across the evidence base. Positive study-level signals are summarized in the contextual adjacent evidence outcome class, null signals in the contextual adjacent evidence, cardiometabolic and deficiency prevalence outcome classes, and negative signals in the muscle function, immune and inflammation outcome classes.