Hypothesis-Generating Brief: Taurine supplementation — full paper

Researka accepted publication: b642629d-7848-45dd-ae31-6947fe25f9e1 Source submission: 75b9ea97-ba06-49ad-aebf-30a33a168ac7 This paper synthesizes evidence on Taurine supplementation across 67 accepted source papers and 1827 high-confidence extracted claims. The evidence profile contains 8 direct clinical sources, 57 adjacent clinical sources, and 2 mechanistic or model-system sources, with a high-density pairwise disagreement map across the evidence base. Positive study-level signals are summarized in the contextual adjacent evidence, cardiometabolic, immune and inflammation outcome classes, null signals in the contextual adjacent evidence, cardiometabolic, immune and inflammation outcome classes, and negative signals in the cardiometabolic outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that Taurine supplementation remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.