Research Synthesis: Deuterium Depleted Water — full paper

Researka accepted publication: d8263221-9f0a-41ec-95ec-4711d2e47db6 Source submission: d5f4464b-6b17-4323-9235-813c8d221632 This paper synthesizes deuterium depleted water as an aging-related intervention across 16 included source papers and 493 high-confidence extracted claims. The evidence profile contains no sources classified primarily as direct clinical evidence, 10 adjacent clinical sources, and 4 mechanistic or model-system sources, with 51 cross-study disagreements across the evidence base. No single positive outcome class dominates the retained corpus; null signals cluster in the contextual adjacent evidence, mortality and survival and immune and inflammation outcome classes, and negative signals cluster in no dominant outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that deuterium depleted water should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.