Research Synthesis: Metformin Treatment Effects — full paper

Researka accepted publication: 04a4e243-1f41-43e8-9394-cf52f62997db Source submission: ee61e5c4-f17e-4dd4-889e-663a3f99015a This paper synthesizes evidence on metformin treatment effects across 56 accepted source papers and 3357 high-confidence extracted claims. The evidence profile contains 6 direct clinical sources, 27 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 484 cross-study disagreements across the evidence base. Positive study-level signals are summarized in the cardiometabolic and contextual adjacent evidence outcome classes, null signals in the contextual adjacent evidence, cardiometabolic, dosing and pharmacokinetics outcome classes, and negative signals in the cardiometabolic, contextual adjacent evidence, safety and comorbidity outcome classes. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that metformin treatment effects remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.