MechanismsHumans3,000 participantsCohort study

Distinct Multiomic Signatures Reveal Metabolic Mechanisms of Frailty Independent of Chronological Age

GSA 2025 Abstract

Abstract

Frailty is a heterogeneous clinical syndrome characterized by decline in the functioning of multiple physiological systems. Despite its prevalence, the molecular mechanisms mediating frailty remain poorly understood.

The paper

Rappaport N, Zhu D, Pflieger L et al.

GSA 2025 Abstract · 31 Dec 2025 · CC BY

Presented at GSA 2025

doi.org/10.1093/geroni/igaf122.2368