MF-300

Intervention1 paper3 findings

  • Animals1

Outcomes

3

Contraction rate

upin mice1Very low certainty

1 study

  1. MF-300 improves contraction rate in mice.

    “MF-300 10 mg/kg showed a significant increase in absolute (p=0.0003) and specific muscle force (p=0.02), as well as contraction rate (p=0.0068), of the extensor digitorum longus”

    Animalsaged miceextensor digitorum longus10 mg/kg12 weeks

    MF-300 (15-PGDH ENZYME INHIBITOR) REVERSES AGE-RELATED MUSCLE WEAKNESS IN MICE BY RESTORING MUSCLE QUALITY · GSA 2024 abstract · 31 Dec 2024

Contraction rate →

Muscle force

upin mice1Very low certainty

1 study

  1. MF-300 improves muscle force in mice.

    “MF-300 10 mg/kg showed a significant increase in absolute (p=0.0003) and specific muscle force (p=0.02), as well as contraction rate (p=0.0068), of the extensor digitorum longus”

    Animalsaged miceextensor digitorum longus10 mg/kg12 weeks

    MF-300 (15-PGDH ENZYME INHIBITOR) REVERSES AGE-RELATED MUSCLE WEAKNESS IN MICE BY RESTORING MUSCLE QUALITY · GSA 2024 abstract · 31 Dec 2024

Muscle force →

Muscle specific force

upin mice1Very low certainty

1 study

  1. MF-300 improves muscle specific force in mice.

    “After 12 weeks of treatment, MF-300 10mg/kg significantly increased maximal muscle force (p< 0.0001) and specific force (p=0.02) in aged animals compared to vehicle.”

    Animalsaged miceplantar flexor muscle10 mg/kg every other day12 weeks

    MF-300 (15-PGDH ENZYME INHIBITOR) REVERSES AGE-RELATED MUSCLE WEAKNESS IN MICE BY RESTORING MUSCLE QUALITY · GSA 2024 abstract · 31 Dec 2024

Muscle specific force →

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