DHCR24 INSUFFICIENCY PROMOTES VASCULAR ENDOTHELIAL CELL SENESCENCE AND ENDOTHELIAL DYSFUNCTION

Abstract

Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other than enzymatic activity, has been involved in age-related disease. However, little is known about the relationship between DHCR24 and vascular ECs senescence.