Small mitochondria-targeting compound SMIP004 selectively eliminates therapy-induced senescent tumor cells by blocking AMPK-dependent PDHA stabilization and improves the outcomes of chemotherapy

Abstract

Therapy-induced senescence (TIS) contributes to tumor recurrence and metastasis. Selective elimination of TIS cells by senolytics would be beneficial for cancer treatment. Here, we found that the stabilization of PDHA (catalytic subunit of pyruvate dehydrogenase) in TIS cancer cells relies on the elevated activity of AMPK.

The paper