Cell‐cell signaling drives a pathologic astrocyte state contributing to cognitive decline in Alzheimer's Disease

Abstract

Background: Alzheimer’s disease (AD) is marked by the coordinated emergence of disease‐associated cell states across multiple brain cell types. Among these, an astrocyte subset—Astrocyte 10 (Ast10), defined by high expression of SLC38A2 , SMTN , and CACNA1D —has been linked to cognitive decline in AD.