Accelerated Aging in the Down Syndrome Brain Indicated by Plasma Biomarkers Showing Greatly Increased Rates of Age‐ and Sex‐Associated Neurodegeneration (UCH‐L1 and NfL) and Astrogliosis (GFAP) and by Heightened Neuronal Apoptosis in a Mouse Model of Down Syndrome
AAIC 2025 Abstract
Abstract
Background: Increasing age is the greatest risk factor for developing Alzheimer's disease (AD) and of ‘normal’ cognitive decline. People with Down syndrome/trisomy 21 (DS) have cognitive challenges throughout life and have a near 100% risk of developing AD neuropathology by age 40, with most developing AD dementia by age 60.
