UCH-L1

1. Down syndrome increases UCH-L1 in humans.

   “Plasma concentrations of biomarkers of ongoing neuronal damage (UCH‐L1 and NfL) and gliosis/inflammation (GFAP) in the brain are significantly increased in individuals with DS starting in childhood”

   Humansplasman = 316

   Accelerated Aging in the Down Syndrome Brain Indicated by Plasma Biomarkers Showing Greatly Increased Rates of Age‐ and Sex‐Associated Neurodegeneration (UCH‐L1 and NfL) and Astrogliosis (GFAP) and by Heightened Neuronal Apoptosis in a Mouse Model of Down Syndrome · AAIC 2025 abstract · 24 Dec 2025

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