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bioRxiv

Exercise data from humans, mice and rats get a common scale

A computational reanalysis standardized 1,037 exercise-versus-control comparisons from 448 independent study clusters, covering 20 tissue classes and seven kinds of molecular data.

Paper by Chaoyang Li, Qingqiu Su · Beijing Sport University
Muscle tissue in cross-section contains packed fibers and molecular shapes, with running and resting human figures and small laboratory mice below.

Our read

Interventions
Studied:
Preprint: computational study of humans, mice and rats
What changed:
Molecular exercise results were standardized across 1,037 exercise-versus-control comparisons
The catch:
Exercise responses were measured at different sampling times across studies

Editor of record: Boris Djordjevic · AgingResearch.News

Paper
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Humans, mice and rats were represented in a computational reanalysis of public exercise studies that put their molecular results on a common scale. The researchers defined exercise-versus-control comparisons using information about individual samples. The dataset included measurements of gene activity, proteins and small molecules.

The team also pooled results within 88 groups defined by tissue, exercise approach and type of molecular data. Each pooled analysis covered features measured in at least three independent studies. The researchers graded evidence using criteria set in advance and tested replication in two reference datasets held back for that purpose. They also included curation records, analysis code and a searchable website.

Why it matters

For research on exercise and healthy aging, the resource offers a common basis for looking up molecules, comparing evidence and planning studies.

Caveats

The pooled evidence came from studies that differed in species, tissue, exercise protocol and sampling time. The work is a preprint and has not been peer-reviewed.

Where the evidence stands

Exercise

Worms or flies, mice and humans: replicated by independent labs. Cells: a single group.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended over a year ago with no results on ClinicalTrials.gov and no paper reporting them.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1,412 independent labs in 89 countries
  • 784 findings against
  • 275 trials, 20 with no results posted
  • Funders: National Institutes of Health and others
  • 371 of 7,836 findings with company ties

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