Early handling
Intervention1 paper3 findings
In one mouse preprint, early handling improves locomotor activity and non-spatial memory in APP/PS1 mice and decreases microglial density in the hippocampus.
- Animals1
Outcomes
3Locomotor activity
upin mice1Very low certainty
1 study
Locomotor activity
upin mice1Very low certainty
Early handling improves locomotor activity in mice.
“normalized locomotor activity at 12 months (both p<0.05).”
Animalsin APP/PS1 mice
The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time · bioRxiv · 5 Oct 2026 · Preprint
Microglia density
downin mice1Very low certainty
1 study
Microglia density
downin mice1Very low certainty
Early handling decreases microglia density in mice.
“consistent with a reduction of hippocampal microglia density”
Animalsin APP/PS1 micehippocampus
The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time · bioRxiv · 5 Oct 2026 · Preprint
Non-spatial memory
upin mice1Very low certainty
1 study
Non-spatial memory
upin mice1Very low certainty
Early handling improves non-spatial memory in mice.
“EH improved non-spatial memory at 6 months, consistent with a reduction of hippocampal microglia density”
Animalsin APP/PS1 micebrain
The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time · bioRxiv · 5 Oct 2026 · Preprint