Young plasma-derived exosomes

Young plasma-derived exosomes has been studied in 2 papers since 2025: none in people yet, 2 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 23, 2026: “Young plasma particles increased bone mass in mice”.

Intervention

2 papers study it4 findingsUpdated

1 new paper in 30 daysSee all 2

None of its findings points the other way.

  • 2 independent labs in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 1 more
  • Animals2

What did studies of Young plasma-derived exosomes find?

4

Studies of Young plasma-derived exosomes measured 4 outcomes; the most studied are osteoclast activation (1 study), M2 macrophage polarization (1) and bone mass (1).

Osteoclast activation

downin mouse cells1

1 study
  1. Young plasma-derived exosomes decrease osteoclast activation in mouse cells.

    “and, indirectly, reversed osteoclast activation and rescued osteogenic suppression.”

    Cellsindirect effectosteoclast

    Young plasma particles increased bone mass in mice

    International journal of biological sciences

M2 macrophage polarization

upin mouse cells1

1 study
  1. Young plasma-derived exosomes induce M2 macrophage polarization in mouse cells.

    “Y-Exos delivered YOD1 to activate mTOR in BMMs, driving M2 polarization”

    Cellsthrough delivery of YOD1 and activation of mTORbone marrow-derived macrophage

    Young plasma particles increased bone mass in mice

    International journal of biological sciences

Bone mass

upin mice1

1 study
  1. Young plasma-derived exosomes increase bone mass in mice.

    “In vivo, Y-Exos increased bone mass”

    Animalsovariectomized micebone

    Young plasma particles increased bone mass in mice

    International journal of biological sciences

Vascular repair

upin rats1

1 study
  1. Young plasma-derived exosomes improve vascular repair in rats.

    “The senolytic coatings, with their ability to clear senescent cells, promoted vascular repair.”

    Animalssenolytic-coated bioresorbable scaffoldsabdominal aorta6-month

    Clearance of senescent vascular smooth muscle cells retards aging-related restenosis following bioresorbable scaffolds implantation

    Biomaterials

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 1Oct 2026: 01 paper in 12 months
International Journal of Biological Sciences

Young plasma particles increased bone mass in mice

Experiments in female mice with surgically induced osteoporosis found that young plasma exosomes, tiny membrane-enclosed particles, increased bone mass and favored…Experiments in female mice with surgically induced osteoporosis found that young plasma exosomes, tiny membrane-enclosed particles, increased bone mass and favored anti-inflammatory immune cells.

Mouse studyBones and joints