Young donor hematopoietic stem cell transplantation

1. Young donor hematopoietic stem cell transplantation improves niche cell populations in humans.

   “transplantation of young, but not aged or impaired, donor HSCs normalized niche cell populations and restored niche factors in host mice carrying an artificially harassed niche and in physiologically aged host mice, as well as in leukemia patients”

   Humansin leukemia patients

   Young donor hematopoietic stem cells revitalize aged or damaged bone marrow niche by transdifferentiating into functional niche cells

   Aging cell·May 24, 2023

2. Young donor hematopoietic stem cell transplantation improves niche cell populations in mice.

   “transplantation of young, but not aged or impaired, donor HSCs normalized niche cell populations and restored niche factors in host mice”

   Animalsin host mice carrying an artificially harassed niche and in physiologically aged host mice

   Young donor hematopoietic stem cells revitalize aged or damaged bone marrow niche by transdifferentiating into functional niche cells

   Aging cell·May 24, 2023

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