Yamanaka factors gene therapy

1 paper3 findings

1 lab in 1 country

Funders: Centro de Biología Molecular Severo Ochoa and 4 more

Animals1

Outcomes

3

Extracellular matrix remodelling

upin mice1

1 study

Yamanaka factors gene therapy increases extracellular matrix remodelling in mice.
“increased plasticity, induced by the reorganization of the extracellular matrix”
Animals
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance
Communications biologyMay 24, 2024

More on Extracellular matrix remodelling

Epigenetic markers

downin mice1

1 study

Yamanaka factors gene therapy decreases epigenetic markers in mice.
“This enhancement is closely tied to increased neuronal activation in regions related to memory processes, reversed aging-related epigenetic markers”
Animals
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance
Communications biologyMay 24, 2024

More on Epigenetic markers

Cognitive function

upin mice1

1 study

Yamanaka factors gene therapy improves cognitive function in mice.
“only cyclic, not continuous, expression of YF result in a noteworthy enhancement of cognitive function in adult mice.”
Animals
In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance
Communications biologyMay 24, 2024

Latest

Communications BiologyMay 25

In vivo cyclic overexpression of Yamanaka factors restricted to neurons reverses age-associated phenotypes and enhances memory performance

Experiments in miceInterventions