Worry

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans2

Outcomes

Depressive symptoms

upin humans1

1 study

Worry increases depressive symptoms in humans (t(152)=-2.4, p=0.01).
“The worried group reported greater depression ( t (152)=‐2.4, p = 0.01), trait anxiety ( t (152)=‐2.6, p = 0.01), apathy ( t (152)=‐2.2, p = 0.01) on self‐report measures.”
Humanssubjective cognitive complaintsn = 154
Impact of Worry on Experimental Hippocampal Tasks and Hippocampal Volumetrics in Older Adults with Subjective Cognitive Complaints
AAIC 2025 abstract25 Dec 2025