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Vesicular stomatitis virus

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: Loo och Hans Ostermans Stiftelse för Medicinsk Forskning and 2 more
  • 3 of 4 findings with company ties
  • Animals1

Outcomes

4

Cellular senescence

upin mice1

1 study

  1. Vesicular stomatitis virus induces cellular senescence in mice.

    “VSV infection, both in vitro and in vivo, could significantly induce the upregulation of senescence-associated markers and the secretion of the senescence-associated secretory phenotype (SASP)”

    Animalsin vitro and in vivo

    Vesicular Stomatitis Virus Induces NF-κB-Dependent Senescence to Mediate Persistent Inflammation and Injury

    Viral immunologyMay 22, 2025

More on Cellular senescence

Serotonin

downin rats1

1 study

  1. Vesicular stomatitis virus decreases serotonin in rats.

    “reduced levels of serotonin and its metabolite 5-hydroxyindole acetic acid in the cerebral neocortex and hippocampus”

    Animalscerebral neocortex and hippocampus

    Persistent changes in behaviour and brain serotonin during ageing in rats subjected to infant nasal virus infection

    Neurobiology of agingJan 1, 1992

More on Serotonin

Neurons

downin rats1

1 study

  1. Vesicular stomatitis virus decreases neurons in rats.

    “When examined at 18 months of age they had a severe loss of neurons in the medial and dorsal raphe nuclei in the brain stem”

    Animalsbrain stem

    Persistent changes in behaviour and brain serotonin during ageing in rats subjected to infant nasal virus infection

    Neurobiology of agingJan 1, 1992

Cognitive function

downin rats1

1 study

  1. Vesicular stomatitis virus impairs cognitive function in rats.

    “demonstrated lifelong learning deficits in the Morris maze and impaired exploratory behaviour in the open field test”

    Animals

    Persistent changes in behaviour and brain serotonin during ageing in rats subjected to infant nasal virus infection

    Neurobiology of agingJan 1, 1992

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