Varespladib

Varespladib inhibits insulin secretion in mice.

“Islet perfusion assays also showed that varespladib treatment suppressed the enhanced insulin secretion observed in aged islets.”

Animalspancreatic isletstwo weeks

Inhibiting arachidonic acid generation mitigates aging-induced hyperinsulinemia and insulin resistance in mice

Clinical nutrition (Edinburgh, Scotland)·May 31, 2024

Varespladib decreases hyperinsulinemia in mice.

“improving hyperinsulinemia and hepatic insulin resistance in aged mice but not in adult mice”

Animalsintragastricallytwo weeks

Inhibiting arachidonic acid generation mitigates aging-induced hyperinsulinemia and insulin resistance in mice

Clinical nutrition (Edinburgh, Scotland)·May 31, 2024

Varespladib decreases insulin resistance in mice.

“inhibiting the generation of arachidonic acid with varespladib, an inhibitor of sPLA2, reduced aging-associated diabetes by improving hyperinsulinemia and hepatic insulin resistance in aged mice”

Animalsintragastricallylivertwo weeks

Inhibiting arachidonic acid generation mitigates aging-induced hyperinsulinemia and insulin resistance in mice

Clinical nutrition (Edinburgh, Scotland)·May 31, 2024