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V35

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Animals1

Outcomes

4

Fat mass

downin mice1

1 study

  1. V35 decreases fat mass in mice.

    “We observed increased lean body mass and reduced fat mass in vaccinated N/df mice”

    Animalsin N/df miceseven doses24 weeks

    ACTIVE IMMUNIZATION AGAINST MYOSTATIN AND ACTIVIN A IMPROVES SKELETAL MUSCLE STRENGTH DESPITE GH/IGF-1 DEFICIENCY

    GSA 2024 abstract31 Dec 2024

Lean body mass

upin mice1

1 study

  1. V35 increases lean body mass in mice.

    “We observed increased lean body mass and reduced fat mass in vaccinated N/df mice”

    Animalsin N/df miceseven doses24 weeks

    ACTIVE IMMUNIZATION AGAINST MYOSTATIN AND ACTIVIN A IMPROVES SKELETAL MUSCLE STRENGTH DESPITE GH/IGF-1 DEFICIENCY

    GSA 2024 abstract31 Dec 2024

Motor performance

upin mice1

1 study

  1. V35 improves motor performance in mice (almost 40% vs 20%).

    “almost 40% of the vaccinated df/df mice completed the accelerating rotarod trials, compared to the 20% of placebo-treated counterparts”

    Animalsin df/df miceseven doses24 weeks

    ACTIVE IMMUNIZATION AGAINST MYOSTATIN AND ACTIVIN A IMPROVES SKELETAL MUSCLE STRENGTH DESPITE GH/IGF-1 DEFICIENCY

    GSA 2024 abstract31 Dec 2024

Grip strength

upin mice1

1 study

  1. V35 improves grip strength in mice.

    “we saw increased forelimb grip strength in V13, V07, and V35 vaccinated df/df mice and V07 and V35 vaccinated N/df mice”

    Animalsin df/df and N/df miceskeletal muscleseven doses24 weeks

    ACTIVE IMMUNIZATION AGAINST MYOSTATIN AND ACTIVIN A IMPROVES SKELETAL MUSCLE STRENGTH DESPITE GH/IGF-1 DEFICIENCY

    GSA 2024 abstract31 Dec 2024

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