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v-ATPase inhibition

v-ATPase inhibition has been studied in 1 paper since 2023: none in people yet, 1 in animals. The research so far is in animals. The newest paper, May 23, 2023: “Deacidification of endolysosomes by neuronal aging drives synapse loss”.

Intervention

1 paper studies it1 findingUpdated

See all 1

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Alzheimer's Association and 8 more
  • Animals1

What did studies of v-ATPase inhibition find?

1

Studies of v-ATPase inhibition measured 1 outcome; the most studied are synapse loss (1 study).

Synapse loss

upin cells1

1 study

  1. v-ATPase inhibition increases synapse loss in cells.

    “alkalinization or v-ATPase inhibition, mimicked age-dependent Lys and synapse dysfunction”

    Cells

    Deacidification of endolysosomes by neuronal aging drives synapse loss

    Traffic (Copenhagen, Denmark)

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