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Unique progerin c-terminal peptide

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 2 more
  • Animals1

Outcomes

3

BUB1B

upin human cells1

1 study

  1. Unique progerin c-terminal peptide increases BUB1B in human cells.

    “enhanced the expression of BUBR1 by interfering with the interaction between PTBP1 and progerin”

    Cellsin HGPS

    Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1

    Nature aging2 Feb 2023

More on BUB1B

Progeroid phenotypes

downin mice1

1 study

  1. Unique progerin c-terminal peptide decreases progeroid phenotypes in mice.

    “ameliorated progeroid phenotypes, extending the lifespan of LmnaG609G/G609G mice”

    AnimalsLmnaG609G/G609G mice

    Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1

    Nature aging2 Feb 2023

Lifespan

upin mice1

1 study

  1. Unique progerin c-terminal peptide extends lifespan in mice.

    “extending the lifespan of LmnaG609G/G609G mice”

    AnimalsLmnaG609G/G609G mice

    Unique progerin C-terminal peptide ameliorates Hutchinson-Gilford progeria syndrome phenotype by rescuing BUBR1

    Nature aging2 Feb 2023

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