Undercarboxylated osteocalcin

1. Undercarboxylated osteocalcin improves synaptic transmission in mice.

   “upregulated the expression of synaptic proteins, and restored hippocampal synaptic plasticity”

   Animalsin sustained estrogen deficiency (OVX)hippocampus

   Osteocalcin is a compensatory hormone to protect the nervous system in ovariectomized mice

   npj aging·May 23, 2026

More on Synaptic transmission

1. Undercarboxylated osteocalcin decreases behavioral impairments in mice.

   “long-term ucOCN administration ameliorated behavioral impairments induced by sustained estrogen deficiency”

   Animalsin sustained estrogen deficiency (OVX)

   Osteocalcin is a compensatory hormone to protect the nervous system in ovariectomized mice

   npj aging·May 23, 2026

1. Undercarboxylated osteocalcin decreases behavioral deficits in mice.

   “displayed severe synaptic damage and behavioral deficits at the early stage, which were rescued by exogenous ucOCN supplementation”

   Animalsin ovariectomized Ocn knockout mice

   Osteocalcin is a compensatory hormone to protect the nervous system in ovariectomized mice

   npj aging·May 23, 2026