Treadmill running
Intervention1 paper2 findings
- Animals1
Outcomes
28-OHdG
upin mice1Very low certainty
1 study
8-OHdG
upin mice1Very low certainty
Treadmill running increases 8-OHdG in mice.
“running stress elevated 8-OHdG levels in males, suggesting greater oxidative burden in older males.”
Animalsrunning stressskeletal musclemales
A redox-sensitive JNK-CHOP signaling axis drives running stress-induced mtUPR activation in aged skeletal muscle · GSA 2025 abstract · 31 Dec 2025
Mitochondrial unfolded protein response
upin mice1Very low certainty
1 study
Mitochondrial unfolded protein response
upin mice1Very low certainty
Treadmill running activates mitochondrial unfolded protein response in mice.
“Running induced the putative mtUPR chaperones mtHsp70 in skeletal muscle of older mice and Hsp60 only in older males.”
Animalsthree consecutive sessions to exhaustionskeletal muscle
A redox-sensitive JNK-CHOP signaling axis drives running stress-induced mtUPR activation in aged skeletal muscle · GSA 2025 abstract · 31 Dec 2025