Tobacco exposure

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Funder: National Natural Science Foundation of China
1 of 4 findings with company ties

Humans3

Outcomes

Telomere length

downin humans1−5.3%

1 study

Tobacco exposure decreases telomere length in humans (-5.34%).
“decrease in telomere length of 5.34% among 276,259 participants”
Humansn = 276,259
Early-life exposure to tobacco, genetic susceptibility, and accelerated biological aging in adulthood
Science advances3 May 2024

Associations

Colorectal cancer

upin humans1HR 1.28

1 study

Tobacco exposure raises the risk of colorectal cancer in humans (HR 1.28, 95% CI 1.16-1.42).
“high-PRS individuals with prenatal tobacco exposure had an elevated CRC risk compared to those with low PRS and no exposure (HR 1.28, 95 % CI: 1.16-1.42, P < 0.001).”
Humansin high-PRS individuals
Early-life tobacco exposure, genetic susceptibility and incident colorectal cancer risk in UK biobank: A prospective cohort analysis
Cancer epidemiology3 Jan 2026