Time in range

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Javna Agencija za Raziskovalno Dejavnost RS and 1 more

Cells1

Outcomes

Inflammation

downin human cells1

1 study

Time in range decreases inflammation in human cells.
“A TIR of 70%, but not of 50%, suppressed these effects while a TIR of 85% did not provide additional benefit.”
Cellsendothelial cells and monocytes in vitro
A glucose time in range of 70% attenuates the senescence-inducing and pro-inflammatory effects of hyperglycemia
Cardiovascular diabetology14 Nov 2025

Associations

IL-6

downin humans1

1 study

Time in range is associated with IL-6 in humans.
“A TIR above 70% is associated with attenuated pro-senescence and pro-inflammatory effects of hyperglycemia.”
Humansin individuals with type 1 diabetes adjusted for HbA1cPBMCn = 37
A glucose time in range of 70% attenuates the senescence-inducing and pro-inflammatory effects of hyperglycemia
Cardiovascular diabetology14 Nov 2025

Latest

1 in 12 months

Cardiovascular Diabetology15 Nov

A glucose time in range of 70% attenuates the senescence-inducing and pro-inflammatory effects of hyperglycemia

Experiments in human cellsCellular senescence

Paper

Time in range

Outcomes

Associations

Latest

A glucose time in range of 70% attenuates the senescence-inducing and pro-inflammatory effects of hyperglycemia

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