Thymoglobulin
Thymoglobulin has been studied in 1 paper since 2017: 1 observational study in people. The newest paper, Sep 20, 2017: “Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins”.
1 paper studies it4 findingsUpdated
“By contrast, T cell activation (CD38+DR+Ki67+) and senescence (CD8+CD57+CD28-) was increased in Thymoglobulin-treated patients.”
None of its findings points the other way.
- 1 lab in 1 country
- 7 trials, none about aging, 1 with no results posted
- Funder: Agence Nationale de la Recherche
- Humans1
What did studies of Thymoglobulin find?
3Studies of Thymoglobulin measured 3 outcomes; the most studied are acute rejection (1 study), CD8+CD57+CD28- T cell senescence (1) and CD38+DR+Ki67+ T cell activation (1).
Acute rejection
no changein humans1
1 study
Acute rejection
no changein humans1
Thymoglobulin was not clearly linked with acute rejection in humans (compared with Grafalon).
“Grafalon and Thymoglobulin seem to be equivalent to prevent acute rejection.”
Humanscompared with Grafalonn = 182
Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins
Transplant immunology
CD8+CD57+CD28- T cell senescence
upin humans1
1 study
CD8+CD57+CD28- T cell senescence
upin humans1
Thymoglobulin is linked with higher CD8+CD57+CD28- T cell senescence in humans (one year post-transplant, compared with Grafalon).
“By contrast, T cell activation (CD38+DR+Ki67+) and senescence (CD8+CD57+CD28-) was increased in Thymoglobulin-treated patients.”
Humansone year post-transplant, compared with Grafalonone yearn = 182
Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins
Transplant immunology
CD38+DR+Ki67+ T cell activation
upin humans1
1 study
CD38+DR+Ki67+ T cell activation
upin humans1
Thymoglobulin is linked with higher CD38+DR+Ki67+ T cell activation in humans (one year post-transplant, compared with Grafalon).
“By contrast, T cell activation (CD38+DR+Ki67+) and senescence (CD8+CD57+CD28-) was increased in Thymoglobulin-treated patients.”
Humansone year post-transplant, compared with Grafalonone yearn = 182
Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins
Transplant immunology
What is Thymoglobulin linked with?
1Studies link Thymoglobulin with 1 measure, most often cytomegalovirus disease (1 study).
Cytomegalovirus disease
upin humans1
1 study
Cytomegalovirus disease
upin humans1
Thymoglobulin is linked with a higher risk of cytomegalovirus disease in humans (compared with Grafalon).
“CMV disease (p=0.013) was more frequent in Thymoglobulin-treated patients.”
Humanscompared with Grafalonone yearn = 182
Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins
Transplant immunology
Trial sponsors
Company1 trialPhase 4501 people
Company2 trialsPhase 2151 people
Company1 trialPhase 275 people
Company1 trialPhase 225 people
Company1 trialPhase 1/285 people
Company1 trialPhase 1/214 people